Beyond Microglia—Alzheimer’s Gene PLCγ2 Acts on Synapses, Too
In mice and cultured human neurons, PLCγ2 knockdown thinned out synapses and suppressed neuron firing. Rare loss-of-function PLCγ2 variants hike AD risk 10-fold.
In mice and cultured human neurons, PLCγ2 knockdown thinned out synapses and suppressed neuron firing. Rare loss-of-function PLCγ2 variants hike AD risk 10-fold.
People who had a damaged locus coeruleus accumulated tangles in their medial temporal lobes over the next three years, and their cognition declined.
Known for shuttling APP, the endosomal receptor latches on to tau. Knocking it down in glia reduced tau seeding. The N1358S risk variant ramped it up.
First papers from MoTrPAC initiative report myriad responses to endurance training in multiple organs in rats, including the brain and heart.
In the DIAN familial AD prevention trial, plaque-busting antibody gantenerumab, but not monomer-targeting solanezumab, nudged fluid markers toward normal.
Tauopathy cranks up lipid synthesis in neurons, which slip the fats to microglia. Blocking AMP kinase greases this process.
Amyloid precursor protein CTFs accumulate in lysosomes adjacent to endoplasmic reticulum. This disrupts calcium flow between the organelles.
Scientists find the senescent subtype has a distinct protein signature, but little change in gene expression, causing it to be overlooked in transcriptomic studies.
Autopsy studies suggest that neurofibrillary tangles first appear in the locus coeruleus (LC) of the brainstem. Now, a longitudinal imaging study lends support to that theory. LC degeneration on MRI, a proxy for tangles, precedes tau PET positivity in the medial temporal lobe, and poor cognition, by three years.
To support the dynamic demands of neurotransmission, axons require a steady supply of mRNA for local protein synthesis. A new study reports that thousands of these transcripts arrive on lysosomes. If this mode of transport shuts down, local axon translation falters, mitochondria fail, autophagosomes pile up, and axons degenerate.
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