Might SORL1 Bind Tau in Glia, Fuel Its Aggregation?
The endosomal receptor, well known for shuttling APP, latches onto tau. Knocking down SORL1 in glial cells reduced tau seeding; the N1358S risk variant ramped it up.
The endosomal receptor, well known for shuttling APP, latches onto tau. Knocking down SORL1 in glial cells reduced tau seeding; the N1358S risk variant ramped it up.
The first papers from the MoTrPAC initiative report myriad responses to endurance training in multiple organs in rats, including the brain and cardiovascular system. The data trove is publicly available.
In the DIAN familial AD prevention trial, plaque-busting antibody gantenerumab, but not monomer-targeting solanezumab, nudged fluid biomarkers toward normal.
Tauopathy cranks up lipid synthesis in neurons, which slip the fats to microglia. Blocking AMP kinase greases this process.
Amyloid precursor protein CTFs accumulate in lysosomes adjacent to endoplasmic reticulum. This disrupts calcium flow between the organelles.
Scientists find the senescent subtype has a distinct protein signature, but little change in gene expression, causing it to be overlooked in transcriptomic studies.
Lysosomes deliver a plethora of mRNA transcripts, including those encoding ribosomal subunits and mitochondrial proteins, to axonal terminals for translation.
In a small Phase 2 trial, the GLP-1 analogue lixisenatide stabilized motor abilities over one year in people with early PD.
The neuronal endolysosome system is one of the first to falter in Alzheimer’s disease. What stalls it? C-terminal fragments of amyloid precursor protein disrupting calcium signaling, according to a new study. Cells lacking presenilin 1 and 2 accumulate APP-CTFs in lysosomes at junctions with the endoplasmic reticulum. The CTFs prevent calcium flow from the ER to the lysosome, slowing endolysosomal function.
To support the dynamic demands of neurotransmission, axons require a steady supply of mRNA for local protein synthesis. A new study reports that thousands of these transcripts arrive on lysosomes. If this mode of transport shuts down, local axon translation falters, mitochondria fail, autophagosomes pile up, and axons degenerate.
New in last 7 days
Latest Comments