Neurofilament Light Clears First Hurdle as Bona Fide FTD Biomarker
FDA qualification would streamline the use of plasma NfL to select asymptomatic carriers of pathogenic frontotemporal dementia mutations for enrollment in prevention trials.
FDA qualification would streamline the use of plasma NfL to select asymptomatic carriers of pathogenic frontotemporal dementia mutations for enrollment in prevention trials.
Scientists correlated the PET signal in PSP patients with tau deposits in postmortem brain; the signal arises from neurons and oligodendrocytes.
People born in the 1970s had 15 percent more surface area in their cortices than those born in the 1930s.
Equipped with ApoE3-Christchurch, microglia made short work of tau fibrils, and spewed fewer inflammatory cytokines.
Lecanemab will soon have maintenance dosing and subcutaneous formulations available; FDA advisory committee will consider donanemab June 10.
An adeno-associated virus that binds the transferrin receptor delivered β-glucocerebrosidase throughout the mouse brain.
APOE4 carriers who also have a glycine-to-glutamic-acid substitution in the extracellular matrix protein were much less likely to develop Alzheimer’s disease.
Blood and other in vitro assays will need to meet the same standards as medical devices, including demonstrating diagnostic accuracy.
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